Models for QT prolongation

Medicines and QT Prolongation

Drug induced QT prolongation.

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...

QT prolongation due to roxithromycin.

Roxithromycin and other macrolide antimicrobials are widely used for a broad variety of infections such as upper respiratory tract infection and community acquired pneumonia. Prolongation of the QT interval, torsade de pointes polymorphic ventricular tachycardia, and sudden death are well described but little known adverse reactions common to all macrolides. We report the case of a 72 year old ...

Antipsychotic Medication and QT Prolongation

The QT interval represents ventricular depolarisation and repolarisation. Prolongation of this interval can lead to life-threatening complications. These can include arrhythmias such as Torsades de Pointes and Ventricular Fibrillation, which may ultimately lead to death. Many risk factors have been identified in prolonging the QT interval, one of which is medication commonly used in the treatme...

Dothiepin, Qt Prolongation and Torsades De Pointes

A case is reported of electrocardiographic QT prolongation that was presumbty familial in origin. Torsades de points developed in association with the use ofdothinepin, despite the pmscription of a low dose of this drug.